P-053 Predicators of Mucosal Healing in Ulcerative Colitis

Controversies in mucosal healing in ulcerative colitis.

As clinicians we would all agree that the goal for our patients is to induce remission, which is usually defined as symptom resolution. Restoring continence and absence of rectal bleeding would be signs that the mucosa is at most minimally inflamed if not healed. However, there have not been any data to confirm that symptomatic improvement alters the natural history of the disease, nor decrease...

Mucosal Healing in Ulcerative Colitis – the Fountain of Youth?

Endomicroscopy for assessing mucosal healing in patients with ulcerative colitis.

The assessment of tissue healing has emerged as an important treatment goal in patients with inflammatory bowel disease. In patients with ulcerative colitis (UC), mucosal healing may represent the ultimate therapeutic goal due to the fact that the inflammation is limited to the mucosal layer. Mucosal and histological healing may indicate a subset of UC patients in long-term clinical, endoscopic...

Mucosal healing in ulcerative colitis: surveillance or colectomy?

A 38-year-old patient presented with bloody diarrhea (7 to 8 bowel movements per day), abdominal pain and weight loss. Blood tests showed moderate anemia and an increased Creactive protein. Stool culture and Clostridium difficile toxin were negative. Ileocolonoscopy revealed moderate-severe pancolitis: the mucosa from rectum to cecum showed superficial and deep ulcers, friability and spontaneou...

Mucosal Healing in Ulcerative Colitis--When Zero is Better.

BACKGROUND AND AIMS Extensive evidence has underlined the importance of mucosal healing as a treatment aim for ulcerative colitis (UC). We aimed to assess differences in the incidence of clinical relapse at 12 months between UC patients with Mayo endoscopic scores (MES) 0 and 1. METHODS This retrospective study included consecutive patients in corticosteroid-free remission between 2008 and 20...